More than 1.4 million people worldwide -- including nearly 400,000 people in the United States – have been infected with the new coronavirus, and the number of deaths from the outbreak continues to rise. Officials are attempting to contain the COVID-19 outbreak in the U.S. as hospitals brace for unprecedented patient surges. The Centers for Disease Control and Prevention is tracking cases in the U.S. here. Live updates for Wednesday, April 8, continue below: 2nd US coronavirus vaccine trial administers first dose Update 1:40 a.m. EDT April 8: The first dose of a second experimental novel coronavirus vaccine was administered this week to a subject at the University of Pennsylvania. Biotechnology firm Inovio began its Phase 1 clinical trial with the first dose delivered Monday and the trial expected to enroll as many as 40 healthy adult volunteers in Philadelphia and Kansas City, Missouri, according to a news release. Dr. Pablo Tebas, an infectious disease specialist at the Hospital of the University of Pennsylvania and the study’s principal investigator, said in the release his team anticipates “rapid enrollment” in the early-stage trial, expected to continue through late summer. “There has been tremendous interest in this vaccine among people who want to do what they can do to help protect the greater public from this pandemic as soon as possible,” Tebas said in the release. Meanwhile, biotechnology firm Moderna launched its Phase 1 coronavirus vaccine testing in March. US coronavirus deaths hit 12,895, total cases near 400K Published 12:28 a.m. EDT April 8: The number of novel coronavirus cases in the United States surpassed 398,000 early Wednesday morning across all 50 states, the District of Columbia, Puerto Rico, Guam and the U.S. Virgin Islands. According to researchers at Johns Hopkins University, there are at least 398,809 confirmed U.S. cases of the virus, which have resulted in at least 12,895 deaths. U.S. cases now nearly triple the 141,942 reported in Spain and the 135,586 confirmed in Italy. Of the confirmed U.S. deaths, 5,489 – or roughly 43 percent of the nationwide total – have occurred in New York, 1,232 in New Jersey and 845 in Michigan. In terms of diagnosed cases, New York remains the hardest hit with at least 139,876 confirmed cases – more than three times the next-closest state – followed by New Jersey with 44,416 and Michigan with 18,970. Six other states have now confirmed at least 13,000 novel coronavirus cases each, including: • California: 17,585, including 450 deaths • Louisiana: 16,284, including 582 deaths • Massachusetts: 15,202, including 356 deaths • Florida: 13,629, including 250 deaths • Pennsylvania: 14,956, including 296 deaths • Illinois: 13,553, including 380 deaths Meanwhile, Texas and Georgia each has confirmed at least 9,000 novel coronavirus infections, followed closely by Washington state with 8,696 cases and Connecticut with 7,781 cases; Indiana and Colorado each has confirmed at least 5,000 cases; Ohio, Maryland and Tennessee each has confirmed at least 4,000 cases; Virginia, North Carolina and Missouri each has confirmed at least 3,000 cases; and Arizona, Wisconsin, South Carolina, Alabama and Nevada each has confirmed at least 2,000 cases. Click here to see CNN’s state-by-state breakdown.